For example, after the connectome of the worm were finished, despite it being quite small, for many years it proved to be impossible to simulate the dynamics, because of so many unknown parameters.
This was one of the criticisms that the opponents of connectomics have always brought up. "You spend a lot of money that could have been used for other research, but in the end you do not get a true insight into how the brain really works." For the researchers who thought that knowing all the connections was important, it was an uphill battle to overcome such attitudes.
But one has to start somewhere -- like a genome, the connectome is not the whole story, but it is a very important part of it, on which many other advances can be built up.
Apparently they have been able to simulate dynamics with the fruit fly connectome(?) [0]:
> researchers used the connectome to create a computer model of the entire fruit-> fly brain, including all the connections between neurons. They tested it by activating neurons that they knew either sense sweet or bitter tastes. These neurons then launched a cascade of signals through the virtual fly’s brain, ultimately triggering motor neurons tied to the fly’s proboscis — the equivalent of the mammalian tongue. When the sweet circuit was activated, a signal for extending the proboscis was transmitted, as if the insect was preparing to feed; when the bitter circuit was activated, this signal was inhibited. To validate these findings, the team activated the same neurons in a real fruit fly.
This is certainly very cool. But as the authors themselves point out [1], much more work remains to be done to reproduce more subtle features of the dynamics of the system.
They have a cool website that lets you browse the data: https://codex.flywire.ai/