There is an effect, at least from my perspective, regarding size of cities. It really struck me during a vacation in Sydney. From a certain size on big, read huge, cities tend to break down to almost a cluster of "village communities". within these, you start to know each other. compared to munich for example, there were much more smaller stores and coffee shops right in the center of sydney then in some quarters of munich or any other random german city I know.
In between small and huge you get this ackward feeling anonoumity which stresses you, you get shopping malls out of town, something impossible in Manhatten for example since driving hours to do grocery shopping is just inconvinient. And all that is, I think, not natural to us humans. where this limit between big but not big enough lies, i don't know, maybe it depends on culture... but that's something I tend to see all the time i spend time real big cities. But maybe it's just me.