This cost will compound over time where new frameworks emerge, and components get stuck on older versions of their frameworks.
I can't see this as anything but significant, and not to be minimized. Having multiple redundant libraries on a page is not the direction I would advise anyone to take, particularly not when baked into the accepted best practices. This bodes poorly in the long term.
I've listened to the arguments from web component advocates in blog posts, social media, and videos for years now, and I should be in the target market. But on top of the interop tax, they're full of negatives that aren't present in the mainstream frameworks.
Interop works great within each framework's ecosystem. The same dynamics that cause developers to seek interop cause them to huddle around a small number of mainstream frameworks. So we get a few vibrant ecosystems that push the state of the art together. Web components cannot keep up on the tech side of things, and introduce a ton of complexity to the web platform - ignorable to me as a dev, but not for browser implementers - in service of their early 2010s designs.