One regulation would be banning gambling advertising, for the same reason why smoking ads are (I think?) banned. It is especially nefarious how companies lure in new customers with free bets, often with unscrupulous cash-out conditions, in order to get people hooked. It’s the equivalent of ads providing someone a coupon code to get several boxes of free cigarettes, at which point they get hooked.
Another change I’d like to see is the end of mobile gambling. I’ve never done it, but from watching friends do it, it was far too easy to deposit money, or borrow money on credit, and bet it frivolously. At least if such behavior is confined to a casino, there is some larger barrier to entry for people.
I do not know if this is true in other states, but certain states have the ability for an individual to self-institute a gambling ban at all facilities in the state. I’m not sure if this applies to gambling online. If not, then it should. And if other states don’t have it, then they would greatly benefit from it.
It also seems somewhat fair to me to tax the casinos and other companies profiting from gambling and using that money to fund services for people who become addicted. If you’re going to help create a problem, you should have to help clean it up.