The only effective way I've found to stop seeing stuff from people I dgaf in my feed was to block them.
I was even considering creating a Github repo. with all the usernames I've been selecting out for years, so that people could easily de-shittify their Twitter feed.
The set includes (excludes?):
* the most prominent accounts that post political content; no partisan bias, they're all gone for me
* most major news accounts, including anyone that regularly posts any kind of content related to any side of any war, ever
* "science influencers" where the "science" are actually ads or some deranged guy screaming while wearing a lab coat
* Ian Miles Cheong and the Krassenstein Brothers
* hundreds of e-whores
* hundreds of "I made 1 million dollars last week" accounts
* ... and many more
gg to that