While I am only an armchair physicist and not a professional or academic, the way I like to think of entanglement is as follows.
Any closed system in the universe has certain symmetries/conservation-laws it must follow. Things like "the total amount of energy in there must remain the same", or "the total amount of angular momentum has to remain the same".
Let's look at spin (which is a cousin to classical angular momentum) because that's one of the properties folks like to work with in entanglement experiments.
If you create a new pair of particles, the total spin before they get created is zero, so the total spin after they get created also has to be zero. Thus whatever spin one particle has (when measured along a certain axis) the other has to be opposite.. by dint of our knowledge about the closed system that the particles inhabit.
Saying that they are "entangled" does more to represent the knowledge we have about how the particles were created than it does to represent something special about the particles themselves.
And this entanglement only holds as long as the wave function does not collapse, because that represents the cling-wrap around the fact that they exist within a perfectly closed system. Allowing the particles to interact with their environment in some uncontrolled fashion for example would ruin our closed-system guarantee, thus losing any measurable entanglement. They would not longer be guaranteed to have opposite spin because some other phenomena dumped some un-accounted-for amount of spin into the two-particle system.
So the answer to "How can an entangled system be differentiated from a nonentangled system?" is exactly "Do you have some closed-system guarantee of a precise total amount of spin (or other conserved/symmetric quantity) that all parts of the system must add up to?"
This also means that if some experimenter knows the exact total spin of a given closed system, and another experimenter does not know that total, then the entanglement is only relevant to the experimenter who knows the total.
Does that perspective help? (and/or can any folk better at physics than I confirm or deny my explanation as being sound?)