This is a rare case of the secondary source being much more informative than the official source. They didn't even put links to the original research.
If you highlight the doi.org URL and right click, most modern browsers will allow you to navigate to them.
I hope that “How Side Effects Can Improve Treatment Efficacy: A Randomized Trial" cites Stephen Maturin (~1770-??), a member of the Royal Society and sometime physician in service with the British Navy, who habitually mixed asafoetida powder into medication he compounded for seamen, upon the observation that a foul taste improved both dose-response and adherence to treatment regimem.
I look forward to SCUBBA. Self Contained Underwear Butt Breathing Apparatus.