It's exactly the same molecule "made" in a factory or made naturally from anchovies or seaweed.
It's amazing how such a simple and obviously true rule of thumb gets overthought.
They can also come with ingredients that amplify their negative effects. That's why you usually don't eat your food raw, you cook it or leech out the bad stuff.
But what's your point? Needing to cook food (in most cases) implies you should eat processed food?
Again, overcomplicating a simple, obvious, and useful rule of thumb.