When I used to play, our corp had a subforum devoted to new and upcoming releases so we could figure out the best way to game it. There are several opportunities with each release:
1) Some game-breaking design flaw, such as the one illustrated in this article. CCP is notoriously bad at understanding the impact of changes on the in-game economy, especially when it comes to nullsec and obsessive nerds playing internet spreadsheets. These are obviously the best things to exploit
2) First mover advantage. In almost all new features added, there is a significant first mover advantage. The bigger/more complex the feature, the more money there is to make because it is more difficult for less organized individuals/corps to get into. For example, the wormhole mining and ratting needed considerable logistics to pull off profitably. We had 10-15 individuals working on the project. Everyone had specific roles - some ratted, some mined, some scouted, some dealt with logistics and some dealt with shipping and selling at the market. These exploits can make some pretty good money, and are pretty reliable
3) Scamming. Every new feature opens up new ways to scam people for the latest and greatest thing from CCP. You'd be surprised (or maybe not) about how lucrative this is
4) General income from the new feature, once it's swamped by <everyone else>. Which means margins are razor thin and you should probably look into the next big thing coming down the pipeline.