I couldn't say. I only know that my personal experience of using Rocksmith to learn guitar meant I couldn't bust out a song perfectly without looking at the screen, even if I could get 100% in expert (no visible notation) mode for some songs.
The 60hz refresh visual input was 'expected' by my brain to be there in order to coordinate my body with correct timing, intonation etc. i.e. it seemed to be mixed in with my so called 'muscle memory'.
One other thing that was most noticeable is the gamification noises (e.g. the noise you get for reaching the 25x multiplier) became part of my mental model, and when I recognised this and turned them off in the options, my inability to play that part of song nearly as well became extremely evident, although persisting with the option set to off allowed me to overcome it.