OTOH I have heard Emacs users need Ctrl/Alt constantly while editing.
Actually, on the laptop I'm on, I have Caps Lock mapped to backspace - vanilla unedited colemak layout. On my desktop, I have Caps Lock remapped to LCtrl and LCrtrl mapped to backspace.
Ctrl+u,d for page up and down.
Ctrl+e,y for shifting the screen up and down.
Ctrl+],t for moving in and out of tags (with ctags).
Ctrl+v for visual block mode.
Ctrl+[ instead of escape.
Ctrl+p,n for autocomplete.
Ctrl+r for redo.
Ctrl+o,i navigate location jump history.
...and probably more that I don't know about.
Additionally:
I have Ctrl+h,l mapped for tab switching.
Terminal multiplexers like tmux and screen use Ctrl for switching terminal sessions.
You said you were on a mac so:
System Preferences -> Keyboard -> Modifier Keys