Woolly mammoth 'de-extinction' is nearing reality
livescience.com
livescience.com
However, even if we had pristine copies of mammoth DNA we could not re-create a mammoth.
Complex organisms like mammoths (or humans) are not fully defined by DNA. They are an ecosystem of bacteria and smaller organisms. We don't know the number for mammoths, but about 40% of the cells in the human body are not human. They don't have our DNA. Without them, however, we could not even process food. We get those organisms, not from DNA, but from other humans and the environment around us.
These scientists may be able to create something, and hopefully something that will not suffer horribly, but de-extinction is not nearing realty.
To restore the gut health of humans, there is this thing called "fecal transplant" [1]: use another person's poo to bootstrap the growth of your own gut microbiome.
There is an abundance of mammoth dung in the northern permafrost. When thawed, its microbiome becomes active again, producing methane. [2]
So resurrecting the woolly mammoth as a species is the hardest part. Equipping the first individuals with a proper gut biome will be really easy.
[1] https://en.wikipedia.org/wiki/Fecal_microbiota_transplant
[2] https://www.smithsonianmag.com/science-nature/melting-permaf...
It is really interesting that a mammal can survive without its fauna. The fact that it's possible at all is important.
Axenic mice, however, need to be bred and maintained in isolators and they need to be fed a carefully prepared diet to keep them alive.
In practice, particularly in the context of de-extinction, the overall point still stands. Having the DNA does not mean we can create a viable organism. Is an elephant's fauna "close enough" so the calf can pick it up from the mother and use it?
Maybe?
But we are looking at micro-organisms separated by 10,000 years and from two very different climates, so I'm not sure if the odds are favorable.
== Edit :spelling
That would imply newborns start out as not human and then turn into humans when as they develop a gut biome and people that have distinct biomes are a separate species.
OP never said this. They said complex organisms are not fully defined solely by their DNA. That is a finer point than the one you're engaging with.
It's not just the digestive tract. Our eyes, out lungs, even our skin rely on a huge diversity of specialized and symbiotic organisms to function correctly. This ecosystem evolved in parallel with our DNA, and it's been lost for the mammoth.
Yes, it seems we have the technology to create something with this DNA, but it won't be a mammoth as the organism existed in the past. It may not be viable, and it may suffer horribly.
Aside from that though, it may be important, but there are also lots of cross-species animals (ligers, mules, etc.) that don't get the full bacterial dose from the father of which half of their genetics come from and that doesn't seem to be a main cause of any of their problems that I've heard of.
1.https://www.smithsonianmag.com/science-nature/can-bringing-b... 2.https://longnow.org/ideas/reviving-woolly-mammoth-solve-clim...
There are a myriad of semi-effective ways to mitigate climate change, both at the individual level and corporate/political level.
Breeding up a load of Wooly Mammoths ain't one of them.
> The final dataset consists of 23 woolly mammoth genomes (22 Late Quaternary and one Middle Pleistocene), with 13 at medium coverage (2.3–4.13) and 10 at high coverage (10.4–28.63)
The efforts to make dinosaur like things more fits your description.
They sell grow your own kits at a country store near you
1. [archive link] https://archive.is/QkS7J 2. https://www.smithsonianmag.com/smart-news/this-massive-meatb...
You’d probably be better off farming Homo sapiens or maybe reviving some other species of homo. Put them in gestational pods to harvest their metabolic heat energy. Maybe run mental simulations of various things via neural link.
https://www.bbcearth.com/news/elephant-gestation-period-long...
Seems like the gestation period would make it more of a luxury.
"Today, all species of elephant are hunted specifically for their meat. This occurs notably in Cameroon, Central African Republic, Republic of Congo, and the Democratic Republic of Congo. During ivory hunts by poachers, meat may be taken as a by-product for eventual sale, or to feed the hunting party. As of 2007, wildlife experts expressed concerns that the major threat to elephants may become the demand for meat rather than the ivory trade. Organisations such as the WWF and TRAFFIC are campaigning to reduce consumption levels as this, along with the ivory trade, leads to as many as 55 individuals being killed a day."
No, they didn’t. It’s a myth.
https://www.joh.cam.ac.uk/humans-did-not-cause-woolly-mammot...
I don't know if it's pointless, and there's plenty of room for "pointless" research (because we learn so much in the process). But I do wonder if it's prudent. I think it's cool either way.
That's silly. Goods arriving at East coast ports travel via systems I have no clue about.
Science often brings unexpected fruit. Cloning woolly mammoths may as well.
The moon landing was a propaganda stunt against the USSR. We have no need to revive literal mammoths.
Because is not subject to political time of four years intervals. Politicians lie often about where the funds will arrive, or change their minds after a while. I you can afford it, is much safer this way.
"To produce the calves, Colossal scientists will first identify the genes encoding the woolly mammoth's most emblematic physical traits, such as shaggy hair, curved tusks, fat deposits and a dome-shaped cranium. They will then insert these genes into the genome of closely related, and therefore genetically similar, Asian elephants (Elephas maximus)."
They're not actually taking a full mammoth set of DNA and inserting that into an elephant egg to grow into a mammoth, which they'd done with earlier animals referenced in the article.
Also - how do they know the mother can actually handle it? Seems pretty cruel to make the mother carry an edited child that she might not be capable of handling.
I imagine they would perform a c-section to extract the baby in order to save both mother and calf if it was growing too large.
Now, new species are often disruptive in lots of ways. No reason to think an old one, reintroduced, would be less disruptive. But no mention of real issues like that.
I think the writer was just fishing for something provocative to say.
“Both Asian and African elephants, which Colossal plans to use as surrogates to grow mammoth calves, are endangered, and every elephant gestating a "mammoth" calf can't grow babies of its own. "That's going to reduce population size," Lynch said.“
We risk putting existing endangered species at more risk to try to bring back these past species.
If, as I've been told, grasslands are a better carbon sink than taiga, and mammoths are capable of converting the latter into the former, I'm hopeful for efforts like this.
For instance, existing elephants are already obnoxious destructive animals to have roaming a landscape inhabited by people. It's only fair to include that in the analysis. All part of the equation.
Somebody wanted to reintroduce wolves to Iowa but that got squashed by popular objection. Everyone would have been at risk.
There are probably bigger risks from large deer populations, like Lyme disease, but also other ways of reducing deer populations. And are there other ways of spooking them if that's all it takes to make them more wary of automobiles?
Each year, they account for 59,000 human injuries, 440 human deaths and more than $10 billion in economic loses.
Well, if the currently endangered species go extinct, we'll have the technology to bring them back too ¯\_(ツ)_/¯
> For one, de-extinct animals may be sickly, given that the pool of available DNA for each species is relatively small.
> It's also worth considering who would be liable if large-scale mammoth reintroductions went wrong.
> Reintroductions can lead to clashes between humans and wildlife.
> The makeup of the reintroduced population matters too
> There's also no guarantee that animals will stay where we release them
I have the impression that while each single point may be unlikely, there are (too) many unknowns in the project.
In addition to the biological objections, there are the ideological ones, primarily:
> Instead of using that money to bring back three extinct species whose ecological impact is unknown, the funds could be put toward saving roughly 100 species that are currently facing an uncertain future
I agree that this is ultimately purely driven by profit:
> "If they're successful — and I have no doubt that they will be — they're going to make a ton of money," he said.
If we have to revive something elephant-related, then I'd much prefer them to concentrate on (one of) the Madagascan elephant bird species. The eggs alone would offer a potentially robust revenue stream for whichever God bought the beast back from the dead.
Funny how any effort to arrest the runaway catastrophe that's been caused is met with resistance that calls it 'further damage'. Like we aren't already facing tremendous risks by leaving it unchecked.
Save existing species, go right ahead. That the effort being made to do {absolutely anything else} takes money too, is no kind of argument whatsoever. The aren't exclusive activities.
The risk to elephants in using them for this is a real concern though.
Some humans do on a single continent which has a human population density half that of Eurasia, and even that not particularly smoothly:
https://wwf.panda.org/discover/knowledge_hub/endangered_spec...
Unlike a zebra muscle which one it’s in your local lake goooooood luck ever removing them and now your lake may die a toxic blue green algae death
If it turned out that mammoths were actually a problem, we'd never agree to actually control the population.
It matters from a Chesterton's Fence perspective: We know that the hippos were not brought for any good reason, inevitability, etc.
We do that all the time of course. But I'd kinda like to take at least a moment to consider how we minimize suffering before we plunge ahead.
We know elephants are very intelligent, emotional, and social animals. I see no reason to assume mammoths are significantly different. And of course what they're working aren't even mammoths, more like "hairy elephants".
Cloning a single hairy elephant and keeping it in captivity would consign it to a miserable life of loneliness. It would be nothing short of cruel.
So you managed to clone a herd of hairy elephants, then what do you do with those? The mammoth steppes they once roamed no longer exist. There is no ecosystem to save or improve because that ecosystem is gone. That's what they meant with "what's gone is gone".
Can you just re-introduce them to the wild? These are huge animals that need a lot of space. Other animals and people live there. You can't just have a bit of land; you need a huge amount of it.
Cloning mammoths is just dumb. None of the logistics really work out and a bunch of mammoths spending miserable lonely lives in zoos is basically the best-case outcome we can hope for and after a few decades of this everyone will all realize it was pointless and mammoths will be extinct once more. All these notions are rekindling a lost ecosystem are nothing more than flights of fancy.
For some other animals there is perhaps a slightly better case to be made; I don't know. But for mammoths the case is pretty bad.
Easily solvable if you put it with other elephants. Small elephants bond also with humans.
Would it be that easy?
Imagine a handful of wild humans, having never had any contact with other humans, no education or anything, just put somewhere and left to themselves.
How many centuries would they need to even develop an actual language?
They might very well be totally unable to cooperate or survive at all, without a preexisting society to guide them.
Even if they don't have societies as developed at humans do, I can imagine the same would happen to different degrees with elephants, mammoths, dolphins, crows even.
> How many centuries would they need to even develop an actual language?
https://www.atlasobscura.com/articles/what-is-nicaraguan-sig... https://www.nature.com/articles/34646
I'd say less than 0.1 centuries.
And then the idea that if the population gets out of control, well, we could just cull them. What, because we didn’t do a good enough job the first time?
Sure it could die of a weird disease bc we didn’t have the full genetic code. And yeah I’m equally unconvinced from the article that we actually can do this, but it’s unclear to me what the risks are if we can and do?
Scenario: Bring back one to one hundred wooly mammoths and… X worst case scenario happens. What’s X in your view for the wooly mammoth? I can’t think of any that seem actually bad but maybe my creativity is lacking?
I imagine a big one is the needless and possibly intense pain and suffering for the surrogate mother elephant, and her experimentally-GMO'd calf. Elephants are highly social and by all accounts quite empathetic animals.
Also the opportunity cost - elephant populations are highly endangered and every pregnancy cycle used up for this research is one less actual living elephant.
Why not both? We are 8 billion on this planet, we can fix our mess and do all these crazy things.
And I don't think "de-extinguishing" species is particularly unsafe. Generally, the risk with messing with biology is that things can get out of control, but here, we are talking about extinct species, they went extinct because they were not adapted to the environment we thrive in. By far the most likely result if we screw up is that the specie become extinct again.
I'm not sure how dangerous "de-extinguishing" a species would be, but we've had numerous faux paus with destabilizing ecosystems by introducing non-native species (i.e. lionfish, as an invasive species). These cause extensive environmental damage and can be irreversible if not contained in time. The worst thing that could happen is losing control over the population of de-extinct species and damaging an ecosystem(s).
That all being said, I'd be stumped if we somehow lost sight of a woolly mammoth... and I'd be lying if I said I didn't want to see one myself, so...
What is this, Horizon Zero Dawn? Will we have to steal parts from the mammoth's cauldron facilities for our survival, while the mammoths continue to get stronger and stronger in an unstoppable paperclip optimizing loop?
Being alive is better than not being alive, right?. Even if you experience pain or feel bored. Every animal experiences pain somewhere. Is fine. Is a part of having evolved pain receptors. Those receptors are here for our well-being and safety.
There is nothing special about pain. Is part of our biology.
We have methods to alleviate the pain at birth, why just assume that veterinarians will not use the tools that they have? because vets-bad-duh?
All this pseudo-religious movements that say that all pain must be eliminated at any cost seem totally unhinged. They made promises that can't be fulfilled and they know it.
> Other experts echoed these concerns. "To get some impact, you need to have a lot of animals," Sophie Monsarrat, an ecologist and the rewilding manager at Rewilding Europe, told Live Science.
The target species are all ones that humans (and exceedingly primitive humans, in the case of the mammoth) hunted to extinction, and inadvertently, at that. If there are unintended consequences, why couldn't we just hunt them to extinction again? The species listed in the article are all large, and all mammalian and non-flying avian (Dodo). It's not like they can hide or get away from us easily.
I see what you did there, and I approve.
There are species that are important to our current ecosystem that are going extinct, why are we bringing back mammoths instead of fixing that?
More animals in captivity means that you are increasing the habitat of this species. You can fit more animals from this species in the planet than before.