There's definitely a 0.1% long tail that's tricky with Tailwind (like this), but 99.9% of app styling is so ludicrously fast in Tailwind as compared to writing raw CSS.
Tailwind is unquestionably accelerating drafting up a custom UI, and also makes this much more approachable for webdevs unaccustomed to CSS
The pitfall of declaring all your styles as strings of shorthands in html atts also might never hit you if your UI doesn't get too complex and/or never needs refactoring - but it hits hard if your codebase had grown to a certain scale over the years, and you suddenly need to change or refactor larger parts of the UI
That's the first example on the README.
(Though perhaps the author of this project did a bad job as choosing a representative example of Tailwind code.)
This recent post convinced me to just use CSS again: https://dev.37signals.com/modern-css-patterns-and-techniques...