I've been experimenting with nobuild javascript lately, doing as much as I can with css instead of code, using htmx for the basic stuff, responding to events with clean vanilla js (with jsdoc for types) for what comes next and at some point if I absolutely need to go more complex, I'll build out the functionality using self-contained web components.
No build tool, no meta-compiler, everything is browser ready the second I type it. I might not even minify the code.
I'm not sure the experiment will succeed, but I'm hoping to build a paradigm that works with the browser instead of against it. I'm sure a lot of people will hate it, but I'm so burnt out on the typescript/node/react build chain that I'm having a lot of fun exploring a wildly different approach.