Not sure what "big" means here, but a combination of .pipe, pyarrow, and polars can speed up many slow Pandas operations.
Polars streaming is surprisingly good for larger than RAM. I get that clusters are cool, but I prefer to keep it on a single machine if possible.
Also, libraries like cudf can greatly speed up Pandas code on a single machine, while Snowpark can scale Pandas code to Snowflake scale.