I was seeing the allergist for my eczema and he asked me if I experienced symptom relief when traveling abroad, which I did in Honduras. He thought I may have been exposed to a parasite there that diverted my overactive immune response. go figure.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149054/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856386/
Excess calorie intake causes chronic inflammation, which gradually causes a plethora of other problems. There's also autoimmune conditions as a consequence of viral infections, so many of that from covid in recent years.
If you want to reduce inflammation you should exercise regularly. This seems obvious but, to me, people will come up with conspiracy after conspiracy to explain this. But the basics - moving a bunch - work really well. The American Lifestyle is progressively more and more sedentary, and we're blaming our woes on sunscreen or something.