Well, as the aphorism goes, the best defense is a good offense. Of course Microsoft and Google have security projects which aim to disrupt organized hacking groups, but maybe they need to go further? Like using honey pots to back-feed zero-day exploits (maybe even ones that have been engineered into Google/Microsoft/et al.'s products) to attacker's machines? Go full black-hat (with some sort of plausible deniability) and ransomware the ransomwarers.

As I type this, I realize it sounds a bit like some of the evil all-powerful corporations in sci-fi, although they usually also go to the lengths of assassinating their enemies.

Asymmetry of defense, if you will.