There were two groups I was hoping vanillajsx would resonate with. The first is people who still buy into the React dream but are beginning to be disillusioned with its inability to deliver on its promises, and the second is people who already are fully disillusioned.
I don't know if you've seen it, but Alex Russell just did a blog series where he directly talks about this disillusion and proposes a move away from React for most web apps: https://infrequently.org/series/reckoning/
I am not as anti-React as that myself, but I do agree it is hard to scale up and have it perform well, not at all like the promise. As always, there are no silver bullets and you have to pick a stack that you can understand.
By the way, I made my own pitch for fully vanilla web development here: https://plainvanillaweb.com/