Many many years ago I built Quake 3D model editors. One of the features added in was being able to paint on the 3D model and have it update the original texture. The ability to make little tweaks to texture in-situ was really valuable to fine tune the art asset.
When I watched the video of Stipple Effect, I loved the live output window showing the result of the combined sprites.
The first thing that came to mind was “If I was the artist I would love to draw I the result window and have it update the input sprites for me”
I fully get the challenges with implementing that, but it might be a valuable addition to the workflow, being able to work on the art with one less abstraction level