Sure, and also negative in several significant ways (I am not going to say ton). Some people are able to simply ignore food and get on with their life as thin people. Others can eat whatever they want and remain skinny. Some self medicate with things like nicotine which can induce thinness through appetite suppression and cancer. Many or most in my experience find that they are unable to deal long-term with the noisy, distracting, miserable nature of food cravings and ultimately fall back into their old patterns just to get some relief even if they hate themselves for it.
My favorite metaphor is "how long can you hold your breath?". Sure, you can probably hold your breath for 30 seconds without too much discomfort. Now do it twice. Now hold your breath for 15 seconds every minute. Now 30 seconds for every minute. Uncomfortable? Keep it up. What's the matter, no willpower?
So yes, food and society have been engineered to be profitable at the expense of us consumers but it is exploiting a weakness that not all of us have. Let's just think of these chemicals as eyeglasses for your metabolism and take back some control.