I tried a couple times to get OpenBSD 7.4 and 7.5 booting on EC2 and GCE with no luck (hang during the bootloader). I ended up going with https://openbsd.amsterdam but it would be nice to have working images in the major cloud providers.
I got annoyed with the openssh bugs this summer and figured I should have some hosts I can mostly not worry about.
In general, I think I want OpenBSD to be the Internet-facing hosts as much as possible, so looking into proxy options for TLS+QUIC.
I've used relayd in front of a ruby on rails app that spawns 4 sockets, but I don't see why you would do it for httpd.
Note that httpd is based on relayd and likely still shares a lot of the same code.
Ended up there for more or less the same reason. Shame there isn't more hosted BSD options around.