It's been a few years since the last time I daily drove a Linux desktop. What is the least trouble, yet "power tool" distro and setup people use nowadays?
Or: what do you use?
Or: what do you use?
I use NixOS, these days. It shares a lot of similarities with Silverblue, except it relies on the Nix package manager instead of the RPM one. It's not "the least trouble" by a long-shot, but it has a lot of great built-in tooling that makes developing multiple projects with different packages a breeze. Where other people might use a VM or Docker to isolate build dependencies, us Nix users write specifications for an environment and get a special shell with all our dependencies pre-linked. I digress, but it's a neat project in it's own right that even supports MacOS if it sounds like something you'd want. I've used it in-prod and have nothing but good things to say about it.