However, I think you may be missing the point that the advertisement is specifically meant to elicit, or create, those feelings of guilt or shame. Maybe I feel just fine about the amount I drink, but the wording of the ads subtely implied I should feel guilty about my drinking. If the question was "Do you feel like you could use help with your drinking? Then try Reframe.", then I'd agree with your point more.
But maybe a bad example, because in that case perhaps the end result of the targetted ad could in fact be a better outcome for everyone, as you point out. To pick a bit of a hyperbolic example, what if instead the ad had instead said "Tired of being the the ugliest girl in your class? Try BetterMakeup!" (with all the appropriate imagery the targetting provides). Is advertisement like that truly good for anyone but the seller?
As a bit of a side note, everyone knows ads are targetted now, so there's an implicit assumption on the viewers part that the seller must know something about them. And now advertisers are using that to their advantage.
I think the larger point though is that many of us simply do not think its ethical or healthy to give companies the tools to manipulate our emotions and tap into our insecurities in the pursuit of profit. The seller doesn't care about the buyer, they only care about convincing the buyer to buy their product, even if that means making them feel shitty about themselves.