It might be better by now with the newer GC options (ZGC, G1, Azul). For a while those had their own problems, but I'm a little out of the loop.

Tuning the older options wasn't really all that beneficial. We tried tuning, then running a custom build of OpenJDK to mess with the survivor space (which isn't that tunable via config), then ultimately settled on more aggressive (i.e. weekly) rolling restarts of servers.