For example it's crazy that most pilots are still taught to calculate W&B using printed charts and approximate takeoff performance.
I think you could save more general aviation lives with a fairly minimal system.
A gas gauge sensor that calculates whether you have enough fuel to get to your destination + reserve. Avionics where you input your personal minimums like crosswinds and weather and it warns you if you're about to accept a landing or flight-plan that violates those. Encode that data and send it to ATC via transponder so valuable comm bandwidth is not lost asking for fuel status when emergencies occur.
A gear down warning. It's ridiculous that we still have so many belly landings and consider it a "good" to rely on training and human memory to prevent them. How much cheaper would complex airplanes be if we didn't have the crazy insurance rates due to this?
Angle-of-attack and spin warnings. It's ridiculous that even $1mil+ Cirrus planes can't detect when you're too slow in a base to final turn and sound a warning before you spin. We have the technology, it's foolish to depend on a decades old stall horn!
A system that parses all the hundreds of notams and filters out the important ones.