rapamycin is something i left out yeah, just was something i was less interested in + believe in less. i really only covered sirtuins because its had such a large cultural impact through David Sinclair’s book on aging
From what I've read, he's done quite a bit of this but it's been restricted to a population of one. If his healthspan hits 120, the experiment he's run has been successful, no? He's already 46 so we will have a result relatively soon (within 60-70 years).
Dying at age 48, 80, or 150 are all potentially interesting results.
The amount of testing he undergoes is as interesting as the regimen itself to me. So many things that take you out are very survivable if caught in advance, and he is going to catch everything.
Both are happening; I have no idea what ultimate (or indeed present) limits each has.