That’s probably not possible for the same reason that we don’t get bacteria resistant to things like ethanol and bleach.
https://ehs.weill.cornell.edu/pathogen-resistance-and-disinf...
https://ehs.weill.cornell.edu/pathogen-resistance-and-disinf...
About that... https://www.microbiologyresearch.org/content/journal/micro/1...
[1] https://www.science.org/doi/10.1126/scitranslmed.aar6115
The response letter at the bottom- “Is the effectiveness of alcohol-based handrubs against enterococci really compromised?” by INGEBORG SCHWEBKE has some interesting counterpoints and implies they used 23% isopropanol instead of 70%, which is not enough to sterilize.
So that’s one solution, and it’s a big space for biology to play in. The bigger question will probably be whether or not there’s a route where weeds can make incremental progress toward better resistance from where they are right now.
For insects, as someone else pointed out, the easiest route is probably mimicry. But we might also see insects capable of recognizing the laser bots, noticing the chemical signals of burning bugs, etc.