I handle this by redirecting all questions (anything that isn't a feature request or a bug report) to the project's community forum (hosted on discourse). Then I wrote and deployed https://github.com/pierotofy/issuewhiz to automatically catch and close issues that are identified as questions. GitHub issues is not the place to ask questions, in my opinion.

Here's an example of it in action: https://github.com/LibreTranslate/LibreTranslate/issues/632

It's been working pretty well.