Looks like Reelin has other effects outside the brain, not always positive.
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)006...
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)006...
Coagulation: Reelin promotes thrombus formation.
Atherosclerosis: Reelin promotes inflammation and plaque formation.