> The pharmaceutical company Rexar reformulated their popular weight loss drug Obetrol following its mandatory withdrawal from the market in 1973
> In 1994, Richwood Pharmaceuticals acquired Rexar and began promoting Obetrol as a treatment for ADHD
It's worth reading https://en.wikipedia.org/wiki/Obetrol to understand why it isn't promoted for weight loss. In general, amphetamines are easily abused and can lead to long term health problems.
Because there are very good, fairly obvious reasons to prefer Ozempic over an amphetamine for weight loss.
I am really not the type to seek a “weight loss drug” so I don’t know the state of mind of those who do (big fan of the Maintenance Phase podcast!), it just seems to me if people want focus and weight loss at the same time they might want to consider it.
I see some “it’s an amphetamine” like that means it’s obviously bad. But I guess we all know that “glucagon-like peptide-1 receptor agonists” are totally fine, sure. I think I would posit that amphetamines are more well understood, but I’m no expert.
Certainly I could have realized it would lead to weight loss, I just never really thought of it that way. I can’t be the only one, and I am simply surprised it’s not a part of the broader conversation.
adderall also has some extermely intolerable side effects for a lot of people
This doesn't have to happen. Many people (including me) happily stay on the same dose for years.
Most common fix is take magnesium supplements (threonate is best, oxide worst), but in general Adderall/Vyvanse effects are unusually sensitive to your diet.
People have used amphetamines and other stimulants for weight loss pretty much forever. The reason responsible medical professionals don't prescribe them for such (anymore) is because the risk/reward profile is bad. That doesn't mean it's bad if you need the stimulant -- that changes at least the reward side of the risk/reward tradeoff, so it's totally reasonable to come to a different determination.
The addiction potential for most amphetamines is through the roof and the side effect profiles are fairly intense and mostly negative for a lot of people.
Yes, we do know that amphetamines are bad for weight loss and we know that GLP-1is are good for weight loss. This isn't because amphetamine bad, GLP-1i good, but because we've done clinical trials and determined this to be true.
Here's the thing... Unless you (err, uhm) need an amphetamine, they really have nasty side effects and can lead to serious health problems.
IE, in the 1960s and 1970s they were used for weight loss, and they were pulled from the market for good reason. You can go do the digging needed to find out why, but the cliff notes reason is that amphetamines increase risk of heart attack, and for many people cause amphetamine psychosis when used for extended periods of time.
You'll both love this Joe Rogan Guest:
https://www.youtube.com/watch?v=yUsJIcqwARk
>>Norman Ohler is an author and screenwriter whose books include "Blitzed: Drugs in Nazi Germany," "The Bohemians: The Lovers Who Led Germany's Resistance Against the Nazis," and "Tripped: Nazi Germany, The CIA and the Dawn of the Psychedelic Age."
He talks a lot about the history of the making of and marketing and use of meth from its discovery and used by nazis, military, cia, etc...
Its fantasic.
You will also get these effects with caffeine and cocaine.