Kim Stanley Robinson Sees Humans Colonizing the Solar System in 2312
wired.com
wired.com
My thought is the key to escape from the bounds of solar system is having the technology to encoding/decode/mimic the human reproductive cycle into a non biological format. Thus, after a 50,000 year sub-light speed journey, humans could be reconstituted in any environment able to support life. While the Earth my be long-gone at the end of such a journey, the human species will be be the seed that starts the chain of colonization though-out the universe.