Why do some people lose more weight through exercise than others?

But where I disagree with the author is the prediction that it will lead to a new weight loss drug. That is because I am doubtful that a drug company can patent a protein which is naturally in the body. I think it is more potentially an opportunity for an entrepreneur. Many others can probably produce PGC-1A but the first to build a durable brand around it and educate people to its value will win big.

There's a study being done on humans that is trying to answer this and other questions.