A user doesn’t have to do anything wrong for the computer to become compromised, or even if they do, being able to limit the blast radius and lock down the computer or at least after the fact have collected the data to be able to identify what went wrong seems important.
How would you secure a network of computers without an agent that can do anti-virus, detect anomalies, and remediate them? That is to say, how would you manage to secure it without doing something that has monitoring and lockdown capabilities? In your words, signaling that you do not trust the users?