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Not sure what GP had in mind, but one can programmatically generate PDFs directly, without using something like Typst as a "middleman".

Have you tried doing that? It’s no fun at all and far from easy. I don’t quite see a benefit in doing it without some utility.

Besides, the generation of PDF reports is usually decoupled from the templates, so you will have to work on your own "middleman".

I guess some webkit solution like wkhtmltopdf

How is that more efficient than Typst exactly?

Apache iText, for example.