This is an advantage of hiDPI screens that hadn't quite clicked for me before - a throwback to one of the advantages of CRTs, allowing multiple resolutions to look good on a single display.
This results in both blur (ngligible with a high enough resolution, but doesn't seem to be the case here, seeing the Safari vs Chrome comparison) and a performance hit.
See the Safari/Chrome comparison in the article to see what this means in real terms...
Given the 'free' GPU we get with machines these days (and by free I mean its always included) it seems reasonable to use its oversampling anti-aliasing feature for desktop display. I'm not sure why you wouldn't do that unless it was some sort of power issue.