This is actually not quite true. MDF is purely a formula based on pot size and the bet size (pot size / pot size + bet size). The fact that it doesn't consider various ranges is why it's not really useful - it was a simplified formula used to try to understand the game before solvers existed.
There are situations where your opponent can bet any two cards profitably and you do have to fold - imagine they bet the size of the pot, but have the better hand 99% of the time, you're simply forced to let them bluff the 1% of the time they're bluffing. MDF is a pre-solver concept and not an especially useful concept in the modern game.