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Comment by empath75 | Hacker News Reader

I can't think of anything in the world I would enjoy doing less than completing "a simple auditory–visual matching task" while in an MRI scanner on shrooms.

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The set and settings researchers typically use for usual psych studies are going to bias psychedelic results so much. Think that building you hated in undergrad's crusty unlit cinderblock basement with no windows but coated in cameras and microphones. Its so dystopian, you are literally a caged rat. I don't think you can perform this research in good faith without having experienced a proper trip yourself. It's just impossible to put into words much less gleam any actual understanding from written description of it.

Science needs more Albert Hoffman's who are willing to couple their knowledge with this experience without fear of being fired from IRB violation and ostracized by the scientific community. Otherwise we will forever be grasping in the dark with these drugs.

gleam -> glean

Too late to edit :(

I would suggest the world needs more Shulgins as well.

https://en.wikipedia.org/wiki/Alexander_Shulgin

I've never had a good trip indoors. My brain has a knack for staying grounded by familiar settings, so I hardly even experience the trip. Put me outdoors in the dark and my brain can be stimulated by natural sounds which are not nearly as predictable as those I find indoors. I think it has to do with processing stimuli that I can't instantly attribute to something I know very well. I am also normally hypervigilant, which may come into play since I think familiar settings inhibit my ability to fall under the effects of intoxication somewhat. I am also much more likely to try and sleep off any overwhelming feelings if I'm in the aafety/comfort of a house vs the middle of the forest. Setting doesn't necessarily mean the 'safest' space for you since my own home negatively effects the overall experience.

Having someone who is experienced, sober and willing to guide you for hours (lots of trust) is crucial since the opti.al setting may not be the safest setting.

TL;DR - I struggle to trip or even enjoy a trip indoors. I have always felt shrooms work best when you let them help you attune to nature. Listening to the wind, trees, insects, etc... it's like washing your eyeballs with kittens.

SAME!

I'm often just bored. and on shrooms. Which is fine, just a bit unpleasant.

Very good points. My understanding from talking to a research assistant, the research groups doing lsd/mdma/psilocybin studies based in Basel and Zürich are led by drug experienced researchers.

Indeed, the best setting is in nature on a beautiful day

Or a beautiful star filled night.

I agree, they can already be mentally uncomfortable if you don't like enclosed spaces. Perhaps there's some kind of psychotherapeutic techniques used prior to getting in the MRI during the come up period, to kind of boost positive emotion about the whole process.

Haha I wouldn't. People have made such a big deal out of this drug requiring set and setting but I've swum in the ocean, played soccer, watched movies and TV, played board games and all with great fun. Indoors and outdoors. It's fantastic.

Then your trips did indeed have good set and setting.

Aye, but I didn't try. Folks made it sound like the world would implode if I didn't have a trip sitter.

Agreed. Being in an MRI sounds like you are in the middle of a warzone. With constant sounds that sounds somewhat like gunshots. That would be pretty terrifying on shrooms.

You also cannot move or else the resultant images will be blurry.

I have a pinched nerve in my back/shoulder that becomes very aggravated when laying flat on my back. It took 45 mins to do the MRI and we managed to not have to do any re-takes. I was so uncomfortable from eating the pain that I threw up as soon as I exited the machine. I simply couldn't imagine someone who is tripping trying to sit still that long (ignoring the auditory/spacial effects all together).

warzone? have you been in an MRI? or shot guns?

it sounds like being on an airplane next to one of the engines. constant woosh. nothing at all like a warzone, or even a moderately busy range.

would be disconcerting as hell on drugs, but that's cuz it is even 100% sober -- it's a weird experience being in an MRI.

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