I’m going to go out on a limb and assume that a comparison between the Trump and Biden administrations in efforts to police the telecom industry would show a marked difference in both effort and effectiveness.
Trump: Ajit Pai (https://en.wikipedia.org/wiki/Ajit_Pai)
Biden: Jessica Rosenworcel (https://en.wikipedia.org/wiki/Jessica_Rosenworcel)
For Rosenworcel, her primary focus seems to be a focus on restoring Net Neutrality. For Pai, his primary focus was on its repeal. The two both share a focus on broadband access and marketing radio spectrum. In terms of banter, Pai is certainly more of a "the free market" personality, and Rosenworcel is more of a "top-down regulation" personality.
Regarding impact, I would characterize their offices as substantially unique only in the context of Net Neutrality.