Doctors and dentists.
Most of the calls I get are spam, but then the MOST important calls I get are from doctors, labs, and dentists. I do as much as possible online of course, but not all of these professionals have good online systems and phone calls are often required.
Sometimes you know what number they're going to be calling from ahead of time, but often you don't... especially if you're in a large medical network that has different offices for different specialists, etc. It's a really sad situation if you get sick and you're trying not to miss these important calls, especially when it's a long wait for a specialist and then you miss their call when they get to your name on the waiting list.
This will literally cost some people their lives and legislators need to act on making spoof calls impossible -- there's no reason why anyone should be allowed to spoof a number that they can't receive calls at.