Yes — because 2FA is commonly stored on a separate device (phone), people are very quick to conclude that it is pointless otherwise without thinking further.

Even if it is stored in your password manager, it is still useful. Consider the case where your network or website is compromised: the password is compromised and can be reused, but the totp 2fa that is in your password manager still prevents login by anyone who obtained your password. There are many attack scenarios but storing 2fa and enabling autocomplete definitely does not make it useless.