'Skinny jabs': weight-loss drugs set for new boom as generic versions emerge | Hacker News Reader

'Skinny jabs': weight-loss drugs set for new boom as generic versions emerge

theguardian.com

9 pointsPaulHoule11 comments

I just recently saw an ad for a pill version of these drugs which I didn't think was possible. Obviously everyone would rather take a pill than get a "jab" every month/week or whatever the cadence is.

Pill version has been out for some time and personally I'd prefer the jab over pill because pill needs to be taken to empty stomach and you can't eat it drink for half an hour after it, every day. Jab on the other hand, takes a few minutes, doesn't even sting and you need to do it only once a week.

Interesting. I have a mild phobia of needles and was perhaps projecting a bit when I suggested everyone would rather take the pill :)

I faint with needles, so I'm with you on that

The pill isn’t great because you need to wait an _entire_ 30 minutes before consuming anything?

Knowing your user is important, I guess.

Well, if routines are easy for you I guess it's not a big deal. If your days are irregular and you often need to figure out when is a good time to take the pill, then it's an additional hassle you can avoid.

Or you can just ignore the instructions and take it whenever but if we go down that road next you know we'll be swimming before thirty minutes has passed after a meal.

This is tangential but I liked your comment. Isn’t it a total fallacy you’re supposed to wait after a meal to swim?

Note that Rybelsus is a pill version of Semaglutide, developed by Novo Nordisk

Wrote a little about it here:

https://glp1.guide/content/a-glp1-ra-drug-without-a-needle-r...

Chemically induced intermittent fasting.

Closer to chemically induced gastroparesis. As someone with this condition I find it baffling that anybody would do it to themselves voluntarily. Not to mention the risk of it being a permanent side effect.

Disclaimer: I'm biased of course -- I run a site that's all about the positive and negative effects of GLP1, but I'm of the opinion that they're positive over-all in the absence of comprehensive nutrition/foodstuff regulation.

The negative side effect of gastroparesis is definitely present, but it's not quite as extreme as you're suggesting here.

A lot of the recent scholarship trying to figure out how GLP1 drugs actually work is more focused on GLP1 receptors in the brain as well. Good write up on it over at the Atlantic:

https://web.archive.org/web/20240305193736/https://www.theat...

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