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Comment by eigenvalue | Hacker News Reader

Would be ironic if the trial shows that the drug works after all this. But that seems incredibly doubtful. This guy should go to prison for a long time. That’s 1,800 people in a trial who could have been taking a non fraudulent drug that has a better chance of working.

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Is there a better and non-fraudulent drug out there? I’m not asking to further an argument, I’m asking because I have a family member with this disease.

Not a drug but intermittent fasting could help, here are some articles on it https://scholar.google.com/scholar?q=intermittent+fasting+Al...

Even if the science isn’t fully there yet, this seems well into the realm of “almost certainly can’t hurt”.

except, well, it kinda might.

https://newsroom.heart.org/news/8-hour-time-restricted-eatin...

Interesting, I wonder if that’s because most people doing so were already or formerly overweight, hence the fasting.

from the newsroom article:

People who followed a pattern of eating all of their food across less than 8 hours per day had a 91% higher risk of death due to cardiovascular disease.

That just fails the laugh test. That can't possibly be true.

There is no published article corresponding to that press release.

There is only this published abstract: https://www.abstractsonline.com/pp8/#!/20343/presentation/37...

(which does not contain the 91% by the way; though it is reported widely. perhaps it was in the presentation).

Here is a page with expert reactions (most are skeptical)

https://www.sciencemediacentre.org/expert-reaction-to-confer...

tl;dr: I don't believe a word of it.

Relatedly, there is evidence that ketogenic (which are fasting mimicking) diets can be helpful:

https://www.ucdavis.edu/health/news/keto-diet-prevents-early....

https://ncats.nih.gov/news-events/news/ketogenic-diet-alzhei...

Yes, this drug from Eli Lilly looks very promising:

https://investor.lilly.com/news-releases/news-release-detail...

https://www.alzheimersresearchuk.org/news/another-milestone-...

Also, the 40hz therapy stuff looks compelling to me. I made a free website that you can use on a phone to try it:

https://alzheimersbuddy.com/

Sadly, there is not a better drug out there.

At best, maybe, progress gets slowed. A little.

The amyloid hypothesis researchers have done grave damage to general society in their intransigence to abandon a position that has been proven over and over to not lead to useful treatments.

and now all citation cartel careers are over?

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