Immune response study explains why some people don't get Covid-19 | Hacker News Reader

Immune response study explains why some people don't get Covid-19

26 pointssusiecambria21 comments

> Using single-cell sequencing, researchers from the Wellcome Sanger Institute, University College London (UCL), Imperial College London, the Netherlands Cancer Institute and their collaborators, studied immune responses against SARS-CoV-2 infection in healthy adult volunteers, as part of the world's first COVID-19 human challenge study.

Link: https://medicalxpress.com/news/2024-06-immune-response-people-dont-covid.html

And link to paper in Nature: https://www.nature.com/articles/s41586-024-07575-x

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I finally succumbed to Covid19 this week, having never shown symptoms, nor testing positive prior. This includes while living in the same household with someone that came down with it from the holidays. Honestly I thought I was immune, but sometimes you're just on the long tail of things.

Archived version of the medicalxpress.com article: https://archive.ph/2024.06.30-162004/https://medicalxpress.c...

There's something about uppers that prevents a person from being vulnerable to viruses, I used to get sick like the flu once a year like clockwork when I lived in Florida, usually right when the cold season started.

I haven't had so much as a bad cough or runny nose, let alone get sick, since I moved to Oregon like 8 years ago (context clues.. lol). So I obviously haven't had Covid either, and I even have a bad nailbiting habit.

Can you elaborate on what “uppers” means in your context? Upper latitudes, altitudes, stimulants, something else?

Amphetamines, cocaine, etc..

In the context of Florida is this really a question?

I don't mean "haha Florida man" necessarily, either, but it's largely sea level and firmly southern US

Yes, because of the difference in legality for many controlled substances between the two states mentioned. From the poster’s reply elsewhere, the context was focusing on Oregon.

> On February 1, 2021, Oregon became the first state in the USA to decriminalize the possession of small quantities of all illicit drugs, following the passing of Oregon Ballot Measure 110 in November 2020.

I guess you put more stock on legality over actions than I do, I dunno. Crime is illegal yet it persists. "It" seemed fairly obvious regarding location/climate/timing.

While you were right to ask, my assumption was also right. I don't mean to belabor this; it was discernible in context.

I’m not sure what you’re talking about so just to be clear: the OC specified it was the legal availability of drugs in Orgeon rather than anything to do with the climate or altitudes of Florida and Oregon. Hope that helps clear up your confusion.

> I’m not sure what you’re talking about

I'll say it more bluntly, then. They were making a weird, stretched, assertion. Your question missed this/bought into it. Consider my first post a joke in poor medium/taste. Sarcasm doesn't translate well.

They confirmed one of your theories (and the one I felt comfortable going with/dismissing) in another comment; vaguely - amphetamines/stimulants.

My point is that it's none of the above. Viral things do better in 'the tropics' during viral seasons than broadly in the north. The drugs make one feel less of the debilitation. Truly ground breaking stuff.

It's a true mystery how communicable diseases do better in favorable and populated/traveled environments. Or how self-prescribing OTC 'analogues' may achieve similar effects. To be clear: /s

This is why I felt the question was silly. I hope that makes sense and clears up your confusion. I don't mean for this to be sour, or belabored... and yet.

This thread is unfounded/on the wrong track from the outset. Avoidable with a little bit of internalization for all three - the other, you, and me.

Ah, I think I see now. I wasn't implying anything beyond asking if the original commenter could clarify their terminology.

(delete)

Quite to the contrary, regular use of amphetamines impairs the immune response, which isn't all that surprising since chronic amphetamine consumption leads to increased stress levels.

Both links are dead. But I never had Covid19 myself, or at least, per my knowledge.

Both links work for me in the UK. Not sure why the OP didn't choose one of them as the headline link though.

EDIT: The medicalXpress one is a summary of the nature article (and links to it), that's more readable to lay people. Honestly, I didn't understand anything in the Nature article, but just about got the gist of the summary article.

Interesting, first link:

>Sorry, the page you were looking for could not be found. The page might have been removed, had its name changed, or become temporarily unavailable.

Second:

>Page not found

If it was just one not working, I'd guess their CDN or geo-IP doesn't work. For two entirely different websites owned by different companies failing, I'd suspect it's more likely to be your DNS that's failing, or maybe your ISP forces a transparent proxy that's broken, etc.

I did try a different ISP, it was the same issue, unless it’s a canada-wide one.

It must be your IP's geography. It doesn't seem like you have normal internet access. It would seem you have only highly-restricted ISP-approved access. Consider complaining to your ISP rather than here.

This is a really weird response to a comment posted… on the internet.

> But I never had Covid19 myself, or at least, per my knowledge.

Same, and I long suspected it was just that I had it, but never showed any symptoms. But when my (live-together) bf had a respiratory problem on the tail end of covid's main brunt, they tested him and stated that he had no signs of every having had it.

I think some of us are just 'lucky' when it comes to this issue, as both me and my bf are immune compromised in a way that would make covid very serious should we catch it.

(Or maybe it's just quantum suicide, and all the universes where one of us caught it, we both died from it ;)

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