There are several big projects that use PGO (like Chrome), and you can get a deterministic build at whatever revision using PGO as the profiles are checked in to the repository.
PGO works just fine in Rust and has support built into the compiler (https://doc.rust-lang.org/rustc/profile-guided-optimization....).
I was under the impression they had switched to AutoFDO across the board but maybe that’s just for their cloud stuff and Chrome continues to run a representative workload since that path is more mature. I would guess that if it’s not being used already, they’re exploring how to make Chrome run AutoFDO for the same reason everyone started using ThinLTO - it brought most of the advantages while fixing the disadvantages that hampered adoption.
And yes, while PGO is available natively, AutoFDO isn’t quite as smooth.
Chrome (and many other performance-critical workloads) is using instrumented PGO because it gives better performance gains, not because it's a more mature path. AutoFDO is only used in situations where collecting data with an instrumented build is difficult.
I’m just using an educated guess to say that at some point in the future Chrome will switch to AutoFDO, potentially using traces harvested from end user computers (potentially just from their employees even to avoid privacy complaints).
Performance is also pretty different on the scales that performance engineers are interested in for these sorts of production codes, but without the build system scalability problems that LTO has. The original AutoFDO paper shows an improvement of 10.5%->12.5% going from AutoFDO to instrumented PGO. That is pretty big. It's probably even bigger with newer instrumentation based techniques like CSPGO.
They also mention the exact reasons that AutoFDO will not perform as well, with issues in debug info and losing profile accuracy due to sampling inaccuracy.
I couldn't find any numbers for Chrome, but I am reasonably certain that they have tried both and continue to use instrumented PGO for the extra couple percent. There are other pieces of the Chrome ecosystem (specifically the ChromeOS kernel) that are already optimized using sampling-based profiling. It's been a while since I last talked to the Chromium toolchain people about this though. I also remember hearing them benchmark FEPGO vs IRPGO at some point and concluding that IRPGO was better.