I haven't worked in this field for a while, but if you look at the citations of the paper [1] there are quite a few applications.

One that I find very interesting is optimizing function layout in binaries to improve their compressibility [2], which is important for mobile apps.

[1] https://scholar.google.com/scholar?cites=1196492606453931313...

[2] https://arxiv.org/pdf/2211.09285