Looking forward toward somebody hooking together Python in APE [0], something like pex [1]/shiv[2]/pyinstaller[3], and the pants build system [4] to have a toolchain which spits out single-file python executables with baked-in venv and portable across mainstream OSes with native (or close enough) performance.
0 - https://news.ycombinator.com/item?id=40040342
1 - https://docs.pex-tool.org/
2 - https://shiv.readthedocs.io/en/latest/