Tangentially, I wonder how much of the research chemical ("legal highs") market is just companies releasing things to gather data for compounds that could be then commercialized.
Cannabis is the closest thing that’s combining the two. MDMA is possible, but I can imagine can be synthesized to remove the euphoria once there has been more testing. Mushrooms, LSD, and Ketamine all show their maximum effectuation at lower doses would be taken recreationally.