The value of the product of two electric charges is invariant to the convention chosen for the sign of the electric charge.
Numbers and numeric quantities are actually a real thing that exists in the world. They do not exist only in our minds (and in the minds of many other animals who are also able to count until some small number). And so does the concept of negation, which clearly is a property of the world, independent of humans or animals.
For other physical quantities, the sign of a quantity is not arbitrary, like for the electric charge, because those are used in expressions that are not invariant to sign changes.