Yes, this is true. But I rarely send emails, it is basically the corporate communication channel these days.

I use a wildcard domain and give each business a different email, for security and privacy. I almost never need to respond.

Generally, when responding, the email is always accepted.

If you have your mail server in order, think SPF, DKIM/DMARC, this rarely if ever happens and when it does you will be notified. These days, i know more private individuals who configured their mail server well than that i know businesses who do.