Nice, what if I have a 3D model and I want to show extra info in a html div about a vertex, edge, face or object that I have selected?
You would do this the same way you would in any other website, have the server send the data required (Hypermedia or not) and use client side JavaScript to do the client side reactivity.
This is like asking why doesn't HTMX allow me to change the colour of a button when I hover over it, why should I have to do this on the client?